Up-regulation of miR-365 promotes the apoptosis and restrains proliferation of synoviocytes through downregulation of IGF1 and the inactivation of the PI3K/AKT …

X Wang, S Gong, D Pu, N Hu, Y Wang, P Fan… - International …, 2020 - Elsevier
… that miR-15b can inhibit the proliferation of chondrocytes by … and joint progressive injury in
patients with significant arthritis, and … apoptosis of melanoma cells through targeting BCL2 and …

[HTML][HTML] miR-142-5p as a CXCR4-targeted microRNA attenuates SDF-1-induced chondrocyte apoptosis and cartilage degradation via inactivating MAPK signaling …

Y Xiang, Y Li, L Yang, Y He, D Jia, X Hu - Biochemistry research …, 2020 - hindawi.com
… It has been demonstrated that miR-15b regulates chondrocytes proliferation and apoptosis
by targeting IGF1, IGF1R, and BCL2 from patients with condylar hyperplasia [17] and …

[HTML][HTML] Effect of condylar chondrocyte exosomes on condylar cartilage osteogenesis in rats under tensile stress

Y Shi, J Shao, Z Zhang, J Zhang, H Lu - Frontiers in Bioengineering …, 2022 - frontiersin.org
… of miR-15b promoted the expression of IGF1, IGF1R, and bcl2, … the proliferation and inhibited
the apoptosis of condylar … It can also target ECE1 and promote MC3T3-E1 cell proliferation, …

Long noncoding RNA LINC00662‐miR15b‐5p mediated GPR120 dysregulation contributes to osteoarthritis

M Lu, E Zhou - Pathology International, 2020 - Wiley Online Library
miR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with
condylar hyperplasia by … by targeting IGF1, IGF1R and Bcl2.14 Another study shows that MiR-…

Regulation of IGF1R by MicroRNA-15b Contributes to the Anticancer Effects of Calorie Restriction in a Murine C3-TAg Model of Triple-Negative Breast Cancer

X Bustamante-Marin, KL Devlin, SB McDonell, O Dave… - Cancers, 2023 - mdpi.com
… that miR-15b could mediate CR’s regulation of IGF1/IGF1R … -3p directly targets mTOR, one
of the key regulation targets of … the reduction of other miR-15b targets such us BCL2, BCL2L2, …

[HTML][HTML] Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

Z Juan, M Xing-Tong, Z Xu, L Chang-Yi - Journal of Dental Sciences, 2023 - Elsevier
miR-15b impedes chondrocyte proliferation by targeting IGF1 and IGF1R and, in turn, promotes
chondrocyte … ) can catalyze Bcl2 mRNA and inhibit chondrocyte apoptosis induced by …

Cartilage tissue miR-214-3p regulates the TrkB/ShcB pathway paracrine VEGF to promote endothelial cell migration and angiogenesis

P Xiao, X Zhu, J Sun, Y Zhang, W Qiu, J Li, X Wu - Bone, 2021 - Elsevier
miR-15b inhibits chondrocyte proliferation through targeting … accelerates chondrocyte apoptosis
through targeting Bcl-2 [13]. … pathways are involved in regulating pain of OA patients [19]. …

Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis

F Wu, Y An, L Zhou, Y Zhao, L Chen, J Wang… - Frontiers in …, 2022 - frontiersin.org
… To name a few, the expression levels of rno-miR-653–5p and rno-miR-15b-3p were …
and reduced apoptosis of chondrocytes through increases in Igf1, Igf1r, and Bcl2 expression…

[HTML][HTML] CircINSR regulates fetal bovine muscle and fat development

X Shen, J Tang, W Ru, X Zhang, Y Huang… - Frontiers in Cell and …, 2021 - frontiersin.org
… the expression levels of miR-15a, miR-15b, miR-16a, and miR-… CCND1 gene is a key regulator
of cell proliferation. The real-… the targeting relationship between miR-15/16 and Bcl-2, we …

Regulatory role of microRNAs in the occurrence and development of osteoarthritis

W Wang, X Liu, C Zhou, J Tian - Chinese Journal of Tissue Engineering …, 2021 - cjter.com
MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients
with condylar hyperplasia by targeting IGF1, IGF1R and BCL2. Osteoarthritis Cartilage. 2019;27(2)…